Digoxin: alternatives to the rest regimen

Authors

  • Javier Guzmán Martínez Médico - Servicio Medicina Interna, Hospital Universitari Sant Joan d’Alacant, Alicante, España https://orcid.org/0000-0002-6526-5873
  • Verónica González Beneyto Médica - Centro de Salud de Mutxamel, Departamento de Salud Sant Joan d’Alacant, Alicante, España https://orcid.org/0000-0003-1949-2204
  • Isidro Hernández Isasi Médico - Servicio Medicina Interna, Hospital Universitari Sant Joan d’Alacant, Alicante, España https://orcid.org/0000-0003-2962-8566
  • Rafael López-Bas Valero Médico - Unidad de Hospitalización a Domicilio, Hospital Universitari Sant Joan d’Alacant, Alicante, España https://orcid.org/0000-0003-2006-9243

DOI:

https://doi.org/10.22585/hospdomic.v6i3.161

Keywords:

Digoxin, Heart failure, Renal failure, Chronicity

Abstract

Introduction: Digoxin is characterized by narrow therapeutic margin which makes its dosing difficult and monitoring of its serum levels necessary. This becomes more complex in patients with chronic nephropathy who require a greater dose adjustment.

Development of the experience: We present the case of an 88-year-old woman admitted to our unit under treatment with oral digoxin for chronic heart failure with a regimen of 1 tablet daily with rest at weekends, who presented poor symptom control and subtherapeutic serum digoxin levels in controls. Changing the formulation to pediatric oral syrup (Lanacordin® 0.05mg/mL) resulted in better drug levels and symptom control.

Conclusions: The use of digoxin in oral syrup may be an alternative to tablet formulation, especially in patients in whom drug level control may be complex due to their comorbidities.

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References

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Published

2022-07-29

How to Cite

Guzmán Martínez, J., González Beneyto, V., Hernández Isasi, I., & López-Bas Valero, R. (2022). Digoxin: alternatives to the rest regimen. Hospital a Domicilio, 6(3), 141–145. https://doi.org/10.22585/hospdomic.v6i3.161

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